3-CHYMOTRYPSIN-LIKE PROTEASE (3CLPRO) OF SARS-COV-2: VALIDATION AS A MOLECULAR TARGET, PROPOSAL OF A NOVEL CATALYTIC MECHANISM, AND INHIBITORS IN PRECLINICAL AND CLINICAL TRIALS

Proteases represent common targets in combating infectious diseases, including COVID-19.The 3-chymotrypsin-like protease (3CLpro) is a validated molecular target for COVID-19, and it is key for developing potent and selective inhibitors for inhibiting viral replication of SARS-CoV-2.In this review, we Emergency Batteries discuss structural relation

Introduction: Recurrent miscarriage is the occurrence of three or more consecutive pregnancy loss before 20 weeks of gestation.Antiphospholipid Antibodies (APAs) are one of the causes responsible for recurrent pregnancy loss.Aim: Estimation of APAs, Anticardiolipin Antibodies (ACAs) and Beta-2 Glycoprotein 1 Antibodies (b-2 GP1 Abs) in Hairclips re

In this work, a new multi-component (CrFeMoNbZr)Ox system was developed.The thin films presented dual-phase amorphous structures, comprising a dominant amorphous alloy phase and a small amount of an amorphous oxide Dishwasher Wheel Support Plate phase.The thin films showed higher hardness and better corrosion resistance than a commercial Zr-based a

The differences between oak lepidopteran communities were studied in Slovakia in 1993 and 1994.Sampling was undertaken between April and October on 3 oak species (Quercus robur, Q.petraea, Q.rubra).Biological traits of larvae were examined in order to explain differences in seasonal guilds among oaks.Communities varied in structure Food Storage and